In vivo quantitative microvasculature phenotype imaging of healthy and malignant tissues using a fiber-optic confocal laser microprobe.

@article{Lin2008InVQ,
  title={In vivo quantitative microvasculature phenotype imaging of healthy and malignant tissues using a fiber-optic confocal laser microprobe.},
  author={Ken Young Lin and Marco A. Maricevich and Nabeel Bardeesy and Ralph Weissleder and Umar Mahmood},
  journal={Translational oncology},
  year={2008},
  volume={1 2},
  pages={84-94}
}
Real-time in vivo imaging of the microvasculature may help both earlier clinical detection of disease and the understanding of tumor-host interaction at various stages of progression. In vivo confocal and multiphoton microscopy is often hampered by bulky optics setup and has limited access to internal organs. A fiber-optic setup avoids these limitations and offers great user maneuverability. We report here the in vivo validation of a fiber-optic confocal fluorescence microprobe imaging system… CONTINUE READING

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