In vivo quantitative measurement of intact fibrous cap and lipid-rich necrotic core size in atherosclerotic carotid plaque: comparison of high-resolution, contrast-enhanced magnetic resonance imaging and histology.

@article{Cai2005InVQ,
  title={In vivo quantitative measurement of intact fibrous cap and lipid-rich necrotic core size in atherosclerotic carotid plaque: comparison of high-resolution, contrast-enhanced magnetic resonance imaging and histology.},
  author={Jianming Cai and Thomas S. Hatsukami and Marina S. Ferguson and William S. Kerwin and T. Saam and Baocheng Chu and Norihide Takaya and Nayak Polissar and C Yuan},
  journal={Circulation},
  year={2005},
  volume={112 22},
  pages={3437-44}
}
BACKGROUND Previous studies with contrast-enhanced magnetic resonance imaging (CEMRI) have shown that the fibrous cap (FC) in atherosclerotic carotid plaques enhances with gadolinium-based contrast agents. Conversely, the lipid-rich necrotic core (LR-NC), lacking both vasculature and matrix, shows no or only slight enhancement. The goal of this study was to assess whether CEMRI can be used to accurately measure the dimensions of the intact FC and LR-NC. METHODS AND RESULTS Twenty-one patients… CONTINUE READING
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