In vivo proton magnetic resonance spectroscopy study on premature aging in adult Down's syndrome.

@article{Murata1993InVP,
  title={In vivo proton magnetic resonance spectroscopy study on premature aging in adult Down's syndrome.},
  author={Tetsuhito Murata and Yoshifumi Koshino and Masao Omori and Ichijiro Murata and Masami Nishio and Toru Horie and Yoshimi Umezawa and Kiminori Isaki and Hirohiko Kimura and Shigeki Itoh},
  journal={Biological psychiatry},
  year={1993},
  volume={34 5},
  pages={290-7}
}
Proton magnetic resonance spectroscopy (1H-MRS) was performed in a group of 18 adult patients with Down's syndrome (DS) aged 20-46 years, and the peak area ratios (NAA/Cr, Cho/Cr, NAA/Cho) of N-acetylaspartate (NAA), total creatine (Cr), and choline-containing compounds (Cho) calculated separately in the patients in their 20's, 30's, and 40's. In age-matched healthy control groups, there were no significant age-related changes in any of the peak area ratios. In contrast, in the DS group… CONTINUE READING
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