In vivo protection by the xanthate tricyclodecan-9-yl-xanthogenate against amyloid beta-peptide (1-42)-induced oxidative stress.

@article{Perluigi2006InVP,
  title={In vivo protection by the xanthate tricyclodecan-9-yl-xanthogenate against amyloid beta-peptide (1-42)-induced oxidative stress.},
  author={Marzia Perluigi and Gururaj G Joshi and Rukhsana Sultana and Vittorio Calabrese and Carlo De Marco and Rafella Coccia and David Butterfield},
  journal={Neuroscience},
  year={2006},
  volume={138 4},
  pages={1161-70}
}
Considerable evidence supports the role of oxidative stress in the pathogenesis of Alzheimer's disease. One hallmark of Alzheimer's disease is the accumulation of amyloid beta-peptide, which invokes a cascade of oxidative damage to neurons that can eventually result in neuronal death. Amyloid beta-peptide is the main component of senile plaques and generates free radicals ultimately leading to neuronal damage of membrane lipids, proteins and nucleic acids. Therefore, interest in the protective… CONTINUE READING