In vivo properties of the proangiogenic peptide QK

@article{Santulli2009InVP,
  title={In vivo properties of the proangiogenic peptide QK},
  author={Gaetano Santulli and Michele Ciccarelli and Gianluigi Palumbo and Alfonso Campanile and Gennaro Galasso and Barbara Ziaco and Giovanna Giuseppina Altobelli and Vincenzo Cimini and Federico Piscione and Luca D D'Andrea and Carlo Pedone and Bruno Trimarco and Guido Iaccarino},
  journal={Journal of Translational Medicine},
  year={2009},
  volume={7},
  pages={41 - 41}
}
The main regulator of neovascularization is Vascular Endothelial Growth Factor (VEGF). We recently demonstrated that QK, a de novo engineered VEGF mimicking peptide, shares in vitro the same biological properties of VEGF, inducing capillary formation and organization. On these grounds, the aim of this study is to evaluate in vivo the effects of this small peptide. Therefore, on Wistar Kyoto rats, we evaluated vasomotor responses to VEGF and QK in common carotid rings. Also, we assessed the… CONTINUE READING

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