In vivo properties of KNT-127, a novel δ opioid receptor agonist: receptor internalization, antihyperalgesia and antidepressant effects in mice.

@article{Nozaki2014InVP,
  title={In vivo properties of KNT-127, a novel δ opioid receptor agonist: receptor internalization, antihyperalgesia and antidepressant effects in mice.},
  author={Chihiro Nozaki and Hiroshi Nagase and Takayuki K. Nemoto and Audrey Matifas and Brigitte Lina Kieffer and Claire Gav{\'e}riaux-Ruff},
  journal={British journal of pharmacology},
  year={2014},
  volume={171 23},
  pages={5376-86}
}
BACKGROUND AND PURPOSE Activation of δ opioid (DOP) receptors regulates pain and emotional responses, and also displays ligand-biased agonism. KNT-127 (1,2,3,4,4a,5,12,12a-octahydro-2-methyl-4aβ,1β-([1,2]benzenomethano)-2,6-diazanaphthacene-12aβ,17-diol) is a novel DOP receptor agonist inducing analgesia and antidepressant effects in mice. Here, we have… CONTINUE READING