In vivo proof of concept of adoptive immunotherapy for hepatocellular carcinoma using allogeneic suicide gene-modified killer cells.

@article{Leboeuf2014InVP,
  title={In vivo proof of concept of adoptive immunotherapy for hepatocellular carcinoma using allogeneic suicide gene-modified killer cells.},
  author={C{\'e}line Leboeuf and Laurent Mailly and Tao Wu and Gaetan Bour and Sarah C. Durand and Nicolas Brignon and Christophe Ferrand and Christophe Borg and Pierre Tiberghien and Robert Thimme and Patrick Pessaux and Jacques Marescaux and Thomas F Baumert and Eric Robinet},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2014},
  volume={22 3},
  pages={634-644}
}
Cell therapy based on alloreactivity has completed clinical proof of concept against hematological malignancies. However, the efficacy of alloreactivity as a therapeutic approach to treat solid tumors is unknown. Using cell culture and animal models, we aimed to investigate the efficacy and safety of allogeneic suicide gene-modified killer cells as a cell-based therapy for hepatocellular carcinoma (HCC), for which treatment options are limited. Allogeneic killer cells from healthy donors were… CONTINUE READING
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