In vivo proliferation advantage of genetically corrected hematopoietic stem cells in a mouse model of Fanconi anemia FA-D1.

@article{Ro2008InVP,
  title={In vivo proliferation advantage of genetically corrected hematopoietic stem cells in a mouse model of Fanconi anemia FA-D1.},
  author={Paula R{\'i}o and N{\'e}stor W. Meza and Africa Gonz{\'a}lez-Murillo and Susana Navarro and Lara {\'A}lvarez and Jordi Surrall{\'e}s and Mar{\'i}a Castell{\`a} and Guillermo Guenechea and Jos{\'e} C Segovia and Helmut Hanenberg and Juan Antonio Bueren},
  journal={Blood},
  year={2008},
  volume={112 13},
  pages={4853-61}
}
Fanconi anemia (FA) is an inherited recessive DNA repair disorder mainly characterized by bone marrow failure and cancer predisposition. Studies in mosaic FA patients have shown that reversion of one inherited germ-line mutation resulting in a functional allele in one or a few hematopoietic stem cells (HSCs) can lead to the proliferation advantage of… CONTINUE READING