In vivo production of thiopeptide variants.

  title={In vivo production of thiopeptide variants.},
  author={Feifei Zhang and Wendy L Kelly},
  journal={Methods in enzymology},
Thiopeptides are a family of highly modified peptide metabolites, characterized by a macrocycle bearing a central piperidine/dehydropiperidine/pyridine ring, multiple thiazole rings, and several dehydrated amino acid residues. Thiopeptides have useful antibacterial, antimalarial, and anticancer properties but have not been adapted for human clinical applications, owing in part to their poor water solubility. In 2009, it was revealed that the thiopeptide scaffold is derived from a ribosomally… CONTINUE READING