In vivo prion protein intestinal uptake in fish.

  title={In vivo prion protein intestinal uptake in fish.},
  author={Andrea Zenone Dalla Valle and Marcello Iriti and Franco Faoro and Cristiana Berti and Salvatore Ciappellano},
  journal={APMIS : acta pathologica, microbiologica, et immunologica Scandinavica},
  volume={116 3},
Intestinal uptake of abnormal prion protein (PrPSc), the pathological agent involved in transmissible spongiform encephalopathies (TSEs), has been investigated in rainbow trout (Oncorhynchus mykiss). Experimental procedures were conducted in vivo by immunohistological PrPSc localization in intestine and pyloric caeca after forced feeding of infected material. Results indicate that PrPSc was absorbed by the intestinal mucosa and that it persisted in the fish gastrointestinal tract for up to 3… CONTINUE READING