In vivo priming with granulocyte colony-stimulating factor possibly enhances the effect of gemtuzumab-ozogamicin in acute myeloid leukemia: results of a pilot study.

@article{Leone2004InVP,
  title={In vivo priming with granulocyte colony-stimulating factor possibly enhances the effect of gemtuzumab-ozogamicin in acute myeloid leukemia: results of a pilot study.},
  author={Giuseppe Leone and Sergio Rutella and Maria Teresa Voso and Luana Fianchi and Alessandra Scardocci and Livio Pagano},
  journal={Haematologica},
  year={2004},
  volume={89 5},
  pages={634-6}
}
Eight elderly patients with relapsed or refractory acute myeloid leukemia were treated sequentially with recombinant human granulocyte colony-stimulating factor with rhG-CSF and Mylotarg. Priming with rhG-CSF in vivo induced an increase in the proportion of CD33+ cycling blasts. Four patients (50% ) achieved a complete remission, 2 patients had a partial remission and the other 2 were resistant. 
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