In vivo presynaptic control of dopamine release in the cat caudate nucleus--II. Facilitatory or inhibitory influence of L-glutamate.

@article{Cheramy1986InVP,
  title={In vivo presynaptic control of dopamine release in the cat caudate nucleus--II. Facilitatory or inhibitory influence of L-glutamate.},
  author={Andr{\'e} Cheramy and R. Aguado Romo and G{\'e}rard Godeheu and P. Baruch and Jacques Glowinski},
  journal={Neuroscience},
  year={1986},
  volume={19 4},
  pages={1081-90}
}
The local effects of various concentrations of L-glutamate (from 10(-8) M up to 10(-3) M) on the release of [3H]dopamine synthesized continuously from [3H]tyrosine were examined in the caudate nucleus of halothane-anaesthetized cats implanted with push-pull cannulae. When used at a concentration of 10(-8) M or 10(-7) M, L-glutamate stimulated the release of [3H]dopamine from nerve terminals of the nigrostriatal dopamine neurons. This effect was still observed in the presence of tetrodotoxin (5… CONTINUE READING

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