In vivo polysaccharide-specific IgG isotype responses to intact Streptococcus pneumoniae are T cell dependent and require CD40- and B7-ligand interactions.

@article{Wu1999InVP,
  title={In vivo polysaccharide-specific IgG isotype responses to intact Streptococcus pneumoniae are T cell dependent and require CD40- and B7-ligand interactions.},
  author={Z Q Wu and Quirijn Vos and Yi Shen and Andrew Lees and Samuel R. Wilson and David E. Briles and William C. Gause and James J. Mond and Clifford M Snapper},
  journal={Journal of immunology},
  year={1999},
  volume={163 2},
  pages={659-67}
}
In vivo Ig responses to soluble, haptenated polysaccharide (PS) Ags are T cell independent and do not require CD40 ligand (CD40L). However, little is known regarding the regulation of in vivo PS-specific Ig responses to intact bacteria. We immunized mice with a nonencapsulated, type 2 Streptococcus pneumoniae (R36A) and compared the parameters that regulated in vivo Ig isotype responses to the bacterial cell wall C-PS determinant, phosphorylcholine (PC), relative to Ig responses to the cell… CONTINUE READING
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