In-vivo phenotyping for CYP3A by a single-point determination of midazolam plasma concentration.

@article{Lin2001InvivoPF,
  title={In-vivo phenotyping for CYP3A by a single-point determination of midazolam plasma concentration.},
  author={Yvonne S. Lin and Graham F. Lockwood and Martin A. Graham and W. R. Brian and Cinnati Loi and Michael R. Dobrinska and Danny D. Shen and Paul B Watkins and Grant R. Wilkinson and Evan D. Kharasch and Kenneth E. Thummel},
  journal={Pharmacogenetics},
  year={2001},
  volume={11 9},
  pages={781-91}
}
We investigated whether a single plasma midazolam concentration could serve as an accurate predictor of total midazolam clearance, an established in-vivo probe measure of cytochrome P450 3A (CYP3A) activity. In a retrospective analysis of data from 224 healthy volunteers, non-compartmental pharmacokinetic parameters were estimated from plasma concentration-time curves following intravenous (IV) and/or oral administration. Based on statistical moment theory, the concentration at the mean… CONTINUE READING

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