In vivo pharmacology of the dopaminergic stabilizer pridopidine.

  title={In vivo pharmacology of the dopaminergic stabilizer pridopidine.},
  author={Henrik Pont{\'e}n and Johan Kullingsj{\"o} and S{\"o}ren Lagerkvist and Peter Martin and Fredrik Pettersson and Clas Sonesson and Susanna Waters and Nicholas Waters},
  journal={European journal of pharmacology},
  volume={644 1-3},
Pridopidine (ACR16) belongs to a new pharmacological class of agents affecting the central nervous system called dopaminergic stabilizers. Dopaminergic stabilizers act primarily at dopamine type 2 (D(2)) receptors and display state-dependent behavioural effects. This article aims to give an overview of the preclinical neurochemical and behavioural in vivo pharmacological properties of pridopidine. Pridopidine was given s.c. to male Sprague-Dawley rats (locomotor, microdialysis and tissue… CONTINUE READING
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