In vivo pharmacology of L-159,913, a new highly potent and selective nonpeptide angiotensin II receptor antagonist.

@article{Gabel1995InVP,
  title={In vivo pharmacology of L-159,913, a new highly potent and selective nonpeptide angiotensin II receptor antagonist.},
  author={R. Gabel and S. Kivlighn and G. Zingaro and T. W. Schorn and L. Schaffer and W. Ashton and L. Chang and K. Flanagan and W. Greenlee and P. Siegl},
  journal={Clinical and experimental hypertension},
  year={1995},
  volume={17 6},
  pages={
          931-53
        }
}
  • R. Gabel, S. Kivlighn, +7 authors P. Siegl
  • Published 1995
  • Chemistry, Medicine
  • Clinical and experimental hypertension
  • The present study was designed to characterize the in vivo pharmacology of L-159,913 (4-[[2'-(N-benzoylsulfamoyl)biphenyl-4-yl]-5butyl-2,4-dihydr o-2- [2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one); a potent All receptor antagonist. In normotensive rats, dogs, rhesus monkeys, and chimpanzees, L-159,913 inhibited All-induced elevations in blood pressure. In conscious rats, the relative potencies (ED50) were 0.51 mg/kg i.v. and 0.72 mg/kg p.o. Duration of action with single i.v. or p.o… CONTINUE READING
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