In vivo pharmacological actions of two novel inhibitors of anandamide cellular uptake.

@article{Lago2004InVP,
  title={In vivo pharmacological actions of two novel inhibitors of anandamide cellular uptake.},
  author={Eva de Lago and Alessia Ligresti and Giorgio Ortar and Enrico Morera and Ana Cabranes and Gareth Pryce and Maurizio Bifulco and David Baker and Javier Fern{\'a}ndez-Ruiz and Vincenzo Di Marzo},
  journal={European journal of pharmacology},
  year={2004},
  volume={484 2-3},
  pages={249-57}
}
Two inhibitors of the cellular uptake of the endocannabinoid anandamide, (R)-N-oleoyl-(1'-hydroxybenzyl)-2'-ethanolamine and (S)-N-oleoyl-(1'-hydroxybenzyl)-2'-ethanolamine (OMDM-1 and OMDM-2, respectively), were recently synthesized, and their in vitro pharmacological activity described. Here we have assessed their activity in two typical pharmacological responses of cannabimimetic compounds. We first examined whether these compounds exert any effect per se on locomotion and pain perception in… CONTINUE READING