In vivo pharmacokinetics, biodistribution and antitumor effect of paclitaxel-loaded micelles based on α-tocopherol succinate-modified chitosan

@article{Liang2016InVP,
  title={In vivo pharmacokinetics, biodistribution and antitumor effect of paclitaxel-loaded micelles based on α-tocopherol succinate-modified chitosan},
  author={N. Liang and Shaoping Sun and Juan Hong and Jingzhuo Tian and Liang Fang and F. Cui},
  journal={Drug Delivery},
  year={2016},
  volume={23},
  pages={2651 - 2660}
}
Abstract In our previous study, α-tocopherol succinate modified chitosan (CS-TOS) was synthesized and encapsulated paclitaxel (PTX) to form micelles. Preliminary study revealed that the CS-TOS was a potential micellar carrier for PTX. In this study, some further researches were done using Taxol formulation as the control to evaluate the micelle system deeply. In vitro cell experiments demonstrated that the cytotoxic effect of PTX-loaded CS-TOS micelles against MCF-7 cells was comparable with… Expand
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References

SHOWING 1-10 OF 25 REFERENCES
In vivo evaluation of novel chitosan graft polymeric micelles for delivery of paclitaxel
  • 28
  • PDF
α-Tocopherol succinate-modified chitosan as a micellar delivery system for paclitaxel: preparation, characterization and in vitro/in vivo evaluations.
  • 61
Paclitaxel-loaded Pluronic P123/F127 mixed polymeric micelles: formulation, optimization and in vitro characterization.
  • 302
Paclitaxel-loaded polymeric micelles based on poly(ɛ-caprolactone)-poly(ethylene glycol)-poly(ɛ-caprolactone) triblock copolymers: in vitro and in vivo evaluation.
  • 75
Paclitaxel-loaded micelles enhance transvascular permeability and retention of nanomedicines in tumors.
  • 45
  • PDF
Biodistribution and bioimaging studies of hybrid paclitaxel nanocrystals: lessons learned of the EPR effect and image-guided drug delivery.
  • 115
  • PDF
Tumor cells-specific targeting delivery achieved by A54 peptide functionalized polymeric micelles.
  • 37
Preclinical and clinical studies of anticancer agent‐incorporating polymer micelles
  • 424
Paclitaxel and its formulations.
  • 863
...
1
2
3
...