In vivo pharmacokinetic-pharmacodynamic relationship and in vitro equivalence of two oral furosemide tablet formulations.

@article{Cuadrado2003InVP,
  title={In vivo pharmacokinetic-pharmacodynamic relationship and in vitro equivalence of two oral furosemide tablet formulations.},
  author={Antonio Cuadrado and Alicia Rodr{\'i}guez Gasc{\'o}n and Rosa Maria Hern{\'a}ndez and Ana M Castilla and Ane de la Maza and Carlos Emilio Franco Yanez and Alicia L{\'o}pez de Oc{\'a}riz and Mar{\'i}a {\'A}ngeles Solin{\'i}s and Jos{\'e} Lu{\'i}s Pedraz},
  journal={Arzneimittel-Forschung},
  year={2003},
  volume={53 5},
  pages={321-9}
}
A randomized, cross-over, open study of bioequivalence between two different furosemide (CAS 54-31-9) formulations was performed; simultaneously, diuretic effects (urine output, sodium, potassium and chloride excretion) were also compared. Both products meet the British Pharmacopoeia specification and the results of a previous in vitro comparative study ensure equivalence of the two dissolution curves. Twenty-four healthy volunteers (male/female) participated in the bioequivalence study. Each… CONTINUE READING