In vivo persistence of expanded clones specific for bacterial antigens within the human T cell receptor alpha/beta CD4-8- subset

@article{Dellabona1993InVP,
  title={In vivo persistence of expanded clones specific for bacterial antigens within the human T cell receptor alpha/beta CD4-8- subset},
  author={Paolo Dellabona and Giulia Casorati and Beat Friedli and Lena {\AA}ngman and Federica Sallusto and Alan Tunnacliffe and Eddy Roosneek and Antonio Lanzavecchia},
  journal={The Journal of Experimental Medicine},
  year={1993},
  volume={177},
  pages={1763 - 1771}
}
We analyzed the T cell receptor (TCR) rearrangements of 100 TCR-alpha/beta CD4-CD8- (double negative [DN]) T cell clones from normal individuals. We found that in four out of six donors this subset contains expanded clones that often account for 0.5% and, in one individual, even 7% of all peripheral blood lymphocytes. By combining limiting dilution analysis and N region oligotyping of polymerase chain reaction amplified TCR cDNA, we could measure the clonal size and show that two of these… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 32 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 54 REFERENCES

Antivirally protective T cell memory to lymphocytic choriomeningitis virus is governed by persisting antigen

S. Oehen, H. Waldner, T. M. Kfindig, H. Hengartner, R.M
  • Zingernagel
  • 1992
VIEW 1 EXCERPT

CD 3 + 4 - 8c ~ / 3 T cell population with biased T cell receptor V gene usage

T. Abo, T. Ohteki, +5 authors K. Kumagai
  • J . Immunol .
  • 1992

CD3+4-8 - c~/3 T cell population with biased T cell receptor

H. Kubota, H. Okazaki, +3 authors N. Minato
  • V gene usage.J. Immunol
  • 1992
VIEW 1 EXCERPT

Lifespan of human lymphocytes subset defined by CD45 isoforms

C. A. Michie, A. McLean, C. Alcock, P.C.L. Beverly
  • Nature (Lond.)
  • 1992
VIEW 1 EXCERPT

Similar Papers

Loading similar papers…