In vivo percutaneous absorption of fragrance ingredients in rhesus monkeys and humans.

@article{Bronaugh1990InVP,
  title={In vivo percutaneous absorption of fragrance ingredients in rhesus monkeys and humans.},
  author={Robert L. Bronaugh and Ronald C. Wester and Daniel A. W. Bucks and Howard Ira Maibach and Royden Sarason},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={1990},
  volume={28 5},
  pages={369-73}
}
The percutaneous absorption of the fragrance diethyl maleate was measured in vivo in human and monkey studies. With the application sites occluded, 54% of the applied dose of the volatile fragrance penetrated human skin in 24 hr compared with 69% absorption in the monkey skin. It was concluded that the monkey is a good model for human skin with regard to the penetration of this fragrance material since no significant difference in the absorption of diethyl maleate was observed. The percutaneous… CONTINUE READING

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