In-vivo particle mediated delivery of mRNA to mammalian tissues: ballistic and biologic effects.

@article{Sohn2001InvivoPM,
  title={In-vivo particle mediated delivery of mRNA to mammalian tissues: ballistic and biologic effects.},
  author={Richard L. Sohn and Mary T. Murray and Katrin Schwarz and J{\'o}zsef Nyitray and P Purray and Andras Franko and Kristine Palmer and Lawrence N. Diebel and Scott A. Dulchavsky},
  journal={Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society},
  year={2001},
  volume={9 4},
  pages={287-96}
}
Biolistic transmission of mRNA provides transient gene therapy to in vivo organs. This study documents particle mediated mRNA transmission to a solid organ and wound healing model using the mRNA of Green Fluorescent Protein to determine optimal delivery parameters. Renal function, bullet penetration, cellular injury, and Green Fluorescent Protein synthesis were quantified. Chimeric human epidermal growth factor-FLAG epitope cDNA or mRNA was transmitted to wounds in normal or steroid treated… CONTINUE READING

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