In vivo parasitological measures of artemisinin susceptibility.

  title={In vivo parasitological measures of artemisinin susceptibility.},
  author={Kasia Stepniewska and Elizabeth A Ashley and Sue J Lee and Nicholas M Anstey and Karen Irma Barnes and Tran Quang Binh and Umberto D'Alessandro and Nicholas P J Day and Peter M. J. M. De Vries and Grant Dorsey and J. G. Kirk A. W. Guthmann and Mayfong Mayxay and Paul Newton and Piero Olliaro and Lyda Os{\'o}rio and Ric N Price and Mark Rowland and Frank M. Smithuis and Walter R. J. Taylor and François H Nosten and Nicholas J White},
  journal={The Journal of infectious diseases},
  volume={201 4},
Parasite clearance data from 18,699 patients with falciparum malaria treated with an artemisinin derivative in areas of low (n=14,539), moderate (n=2077), and high (n=2083) levels of malaria transmission across the world were analyzed to determine the factors that affect clearance rates and identify a simple in vivo screening measure for artemisinin resistance. The main factor affecting parasite clearance time was parasite density on admission. Clearance rates were faster in high-transmission… CONTINUE READING

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World Antimalarial Resistance Network I: clinical efficacy of antimalarial drugs

  • RN Price, G Dorsey, EA Ashley
  • Malar J
  • 2007
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