In vivo parameters influencing 2-Cys Prx oligomerization: The role of enzyme sulfinylation


2-Cys Prxs are H2O2-specific antioxidants that become inactivated by enzyme hyperoxidation at elevated H2O2 levels. Although hyperoxidation restricts the antioxidant physiological role of these enzymes, it also allows the enzyme to become an efficient chaperone holdase. The critical molecular event allowing the peroxidase to chaperone switch is thought to… (More)
DOI: 10.1016/j.redox.2015.08.011


7 Figures and Tables