In vivo p53 function is indispensable for DNA damage-induced apoptotic signaling in Drosophila.

@article{Lee2003InVP,
  title={In vivo p53 function is indispensable for DNA damage-induced apoptotic signaling in Drosophila.},
  author={Joo Hyun Lee and Eunji Lee and Sungjune Park and Euysoo Kim and Jaeseob Kim and Jongkyeong Chung},
  journal={FEBS letters},
  year={2003},
  volume={550 1-3},
  pages={
          5-10
        }
}
p53 is a representative tumor suppressor whose dysfunction is a major cause of human cancer syndrome. Here we isolated flies lacking Dmp53, which encodes the single Drosophila orthologue of mammalian p53 family. Dmp53 null mutants well developed into adults, only displaying mild defects in longevity and fertility. However, genomic stability and viability of Dmp53 mutants dramatically decreased upon ionizing irradiation. Moreover, mutating Dmp53 abolished irradiation-induced apoptosis and reaper… CONTINUE READING
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