In vivo osteogenic response to different ratios of BMP-2 and VEGF released from a biodegradable porous system.

@article{Hernndez2012InVO,
  title={In vivo osteogenic response to different ratios of BMP-2 and VEGF released from a biodegradable porous system.},
  author={Antonio Mendoza Hern{\'a}ndez and Ricardo Reyes and Esther Alonso S{\'a}nchez and Mar{\'i}a Rodr{\'i}guez-{\'E}vora and Araceli Delgado and Carmen {\'E}vora},
  journal={Journal of biomedical materials research. Part A},
  year={2012},
  volume={100 9},
  pages={2382-91}
}
Bone regeneration and vascularization with porous PLGA scaffolds loaded with VEGF (0.35 and 1.75 μg) and BMP-2 (3.5 and 17.5 μg), incorporated in PLGA microspheres, or the combination of either dose of BMP-2 with the low dose of VEGF were investigated in an intramedullary femur defect in rabbits. The system was designed to control growth factor (GF) release and maintain the GFs localized within the defect. An incomplete release was observed in vitro whereas in vivo VEGF and BMP-2 were totally… CONTINUE READING