In vivo osteoarthritis target validation utilizing genetically-modified mice.

@article{Glasson2007InVO,
  title={In vivo osteoarthritis target validation utilizing genetically-modified mice.},
  author={Sonya S. Glasson},
  journal={Current drug targets},
  year={2007},
  volume={8 2},
  pages={
          367-76
        }
}
Osteoarthritis (OA) is a progressive disease of cartilage degradation that significantly impacts quality of life. There are currently no effective treatments and, while a large number of potential therapeutic targets exist, most have not been validated in vivo. The range of OA models in the mouse has dramatically expanded in the last decade, beyond spontaneous models, to include genetically modified transgenic, knockout (KO) and knock-in (KI) mice that can develop premature cartilage… CONTINUE READING

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