In vivo optical imaging of CD13/APN-expression in tumor xenografts.

  title={In vivo optical imaging of CD13/APN-expression in tumor xenografts.},
  author={Angelika von Wallbrunn and Jens Waldeck and Carsten H{\"o}ltke and Michael Zuehlsdorf and Rolf M. Mesters and Walter Heindel and Michael Sch{\"a}fers and Christoph Bremer},
  journal={Journal of biomedical optics},
  volume={13 1},
The metalloexopeptidase CD13/aminopeptidase N (APN) has been shown to be involved in cancer angiogenesis, invasion, and metastasis. Therefore, a CD13/APN-targeted NGR-peptide was labeled with the cyanine dye Cy 5.5 and applied to image tumor xenografts with different APN-expression levels using both planar and tomographic optical imaging methods. In vitro, the peptide-dye conjugate showed a clear binding affinity to APN-positive HT-1080 cells, while negative MCF-7 cells and predosing with the… CONTINUE READING
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