In vivo optical coherence tomography imaging of preinvasive bronchial lesions.

  title={In vivo optical coherence tomography imaging of preinvasive bronchial lesions.},
  author={Stephen C-T Lam and Beau A. Standish and Corisande Baldwin and Annette McWilliams and Jean Bernard Leriche and Adi Gazdar and Alex I Vitkin and Victor Yang and Norihiko Ikeda and Calum MacAulay},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={14 7},
PURPOSE Optical coherence tomography (OCT) is an optical imaging method that can visualize cellular and extracellular structures at and below tissue surface. The objective of the study was to determine if OCT could characterize preneoplastic changes in the bronchial epithelium identified by autofluorescence bronchoscopy. EXPERIMENTAL DESIGN A 1.5-mm fiberoptic probe was inserted via a bronchoscope into the airways of 138 volunteer heavy smokers participating in a chemoprevention trial and 10… CONTINUE READING
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