In vivo occupancy of D2 dopamine receptors by 7-OH-DPAT.

  title={In vivo occupancy of D2 dopamine receptors by 7-OH-DPAT.},
  author={Beth Levant and Gregory N. Bancroft and Craig Selkirk},
  volume={24 1},
7-OH-DPAT has been shown to exhibit selectivity between D2 and D3 dopamine receptors in a variety of in vitro assay systems. Although the drug has been used in a variety of studies to evaluate the behavioral effects of D3 receptor stimulation, the in vivo D2/D3 selectivity of the compound has not been determined. In this study, protection against inactivation by EEDQ was used as a measure of in vivo occupancy of D2 receptors by behaviorally relevant doses of 7-OH-DPAT (0.03-10 mg/kg, s.c.) in… CONTINUE READING

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