In vivo near-infrared fluorescence imaging of integrin alphavbeta3 in brain tumor xenografts.

Abstract

Noninvasive visualization of cell adhesion molecule alpha(v)beta(3) integrin expression in vivo has been well studied by using the radionuclide imaging modalities in various preclinical tumor models. A literature survey indicated no previous use of cyanine dyes as contrast agents for in vivo optical detection of tumor integrin. Herein, we report the… (More)

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