In vivo natural killer cell depletion during primary simian immunodeficiency virus infection in rhesus monkeys.

@article{Choi2008InVN,
  title={In vivo natural killer cell depletion during primary simian immunodeficiency virus infection in rhesus monkeys.},
  author={Elisa I. Choi and Keith A Reimann and Norman L. Letvin},
  journal={Journal of virology},
  year={2008},
  volume={82 13},
  pages={6758-61}
}
The contribution of natural killer (NK) cells to the immune containment of human immunodeficiency virus infection remains undefined. To directly assess the role of NK cells in an AIDS animal model, we depleted rhesus monkeys of >88% of CD3(-) CD16(+) CD159a(+) NK cells at the time of primary simian immunodeficiency virus (SIV) infection by using anti-CD16 antibody. During the first 11 days following SIV inoculation, when NK cell depletion was most profound, a trend toward higher levels of SIV… CONTINUE READING

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