In vivo native fluorescence spectroscopy and nicotinamide adinine dinucleotide/flavin adenine dinucleotide reduction and oxidation states of oral submucous fibrosis for chemopreventive drug monitoring.

@article{Sivabalan2010InVN,
  title={In vivo native fluorescence spectroscopy and nicotinamide adinine dinucleotide/flavin adenine dinucleotide reduction and oxidation states of oral submucous fibrosis for chemopreventive drug monitoring.},
  author={Shanmugam Sivabalan and C Ponranjini Vedeswari and Sadaksharam Jayachandran and Dornadula Koteeswaran and C. Pravda and Prakasarao Aruna and Singaravelu Ganesan},
  journal={Journal of biomedical optics},
  year={2010},
  volume={15 1},
  pages={
          017010
        }
}
Native fluorescence spectroscopy has shown potential to characterize and diagnose oral malignancy. We aim at extending the native fluorescence spectroscopy technique to characterize normal and oral submucous fibrosis (OSF) patients under pre- and post-treated conditions, and verify whether this method could also be considered in the monitoring of therapeutic prognosis noninvasively. In this study, 28 normal subjects and 28 clinically proven cases of OSF in the age group of 20 to 40 years are… 

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Auto-fluorescence spectroscopy is a good method for real-time diagnosis of oral submucous fibrosis because OSF mucosa has a very unique pattern of auto- fluorescence spectrum.