In vivo mutational analysis of YtvA from Bacillus subtilis: mechanism of light activation of the general stress response.

@article{AvilaPrez2009InVM,
  title={In vivo mutational analysis of YtvA from Bacillus subtilis: mechanism of light activation of the general stress response.},
  author={Marcela Avila-P{\'e}rez and Jocelyne Vreede and Yifen Tang and Onno Bende and Aba Losi and Wolfgang G{\"a}rtner and Klaas Hellingwerf},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 37},
  pages={24958-64}
}
The general stress response of Bacillus subtilis can be activated by stimuli such as the addition of salt or ethanol and with blue light. In the latter response, YtvA activates sigma(B) through a cascade of Rsb proteins, organized in stressosomes. YtvA is composed of an N-terminal LOV (light, oxygen, and voltage) domain and a C-terminal STAS (sulfate transporter and anti-sigma factor) domain and shows light-modulated GTP binding in vitro. Here, we examine the mechanism of YtvA-mediated… CONTINUE READING

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