In vivo muscarinic cholinergic receptor imaging in human brain with [11C]scopolamine and positron emission tomography.

@article{Frey1992InVM,
  title={In vivo muscarinic cholinergic receptor imaging in human brain with [11C]scopolamine and positron emission tomography.},
  author={Kirk A. Frey and Robert A. Koeppe and G. Keith Mulholland and D A Jewett and R H Hichwa and Richard L. Ehrenkaufer and James E. Carey and Donald M. Wieland and David E. Kuhl and Bernard W. Agranoff},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={1992},
  volume={12 1},
  pages={147-54}
}
Cerebral muscarinic cholinergic receptors were imaged and regionally quantified in vivo in humans with the use of [11C]scopolamine and positron emission tomography. Previous studies in experimental animals have suggested the utility of radiolabeled scopolamine for in vivo measurements, on the bases of its maintained pharmacologic specificity following systemic administration and the exclusion of labeled metabolites from the brain. The present studies describe the cerebral distribution kinetics… CONTINUE READING
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