In vivo murine studies on the biochemical mechanism of naphthalene cataractogenesis.

@article{Wells1989InVM,
  title={In vivo murine studies on the biochemical mechanism of naphthalene cataractogenesis.},
  author={Peter G Wells and Brody Wilson and B M Lubek},
  journal={Toxicology and applied pharmacology},
  year={1989},
  volume={99 3},
  pages={466-73}
}
The polycyclic aromatic hydrocarbon naphthalene is bioactivated by cytochromes P450 to an electrophilic epoxide intermediate, which subsequently is metabolized to naphthoquinones (NQ) and possibly to a free radical intermediate. These reactive intermediates may bind covalently to lenticular tissues, cause oxidant stress and/or lipid peroxidation, thereby initiating cataracts. To evaluate this hypothesis, male C57BL/6 or DBA/2 mice were treated with naphthalene or one of several naphthoquinone… CONTINUE READING
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