In vivo monitoring of recovery from neurodegeneration in conditional transgenic SCA1 mice

@article{Oz2011InVM,
  title={In vivo monitoring of recovery from neurodegeneration in conditional transgenic SCA1 mice},
  author={G{\"u}lin Oz and Manda L. Vollmers and Christopher David Nelson and Ryan Patrick Shanley and Lynn E. Eberly and Harry T. Orr and Hannah B. Clark},
  journal={Experimental Neurology},
  year={2011},
  volume={232},
  pages={290-298}
}
Reliable and objective markers of neuronal function and pathology that can directly assess the effects of neuroprotective treatments in the brain are urgently needed for clinical trials in neurodegenerative diseases. Here we assessed the sensitivity of high field proton magnetic resonance spectroscopy ((1)H MRS) to monitor reversal of neurodegeneration by taking advantage of a well characterized conditional mouse model of spinocerebellar ataxia type 1 (SCA1), where the cerebellar pathology and… CONTINUE READING
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