In vivo monitoring of pH, redox status, and glutathione using L-band EPR for assessment of therapeutic effectiveness in solid tumors.

Abstract

Approach for in vivo real-time assessment of tumor tissue extracellular pH (pH(e)), redox, and intracellular glutathione based on L-band EPR spectroscopy using dual function pH and redox nitroxide probe and disulfide nitroxide biradical, is described. These parameters were monitored in PyMT mice bearing breast cancer tumors during treatment with granulocyte… (More)
DOI: 10.1002/mrm.23196

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Cite this paper

@article{Bobko2012InVM, title={In vivo monitoring of pH, redox status, and glutathione using L-band EPR for assessment of therapeutic effectiveness in solid tumors.}, author={Andrey A. Bobko and Timothy D. Eubank and Jeffrey L. Voorhees and Olga Vladimirovna Efimova and Igor A. Kirilyuk and Sergey Petryakov and Dmitrii G Trofimiov and Clay B. Marsh and Jay L. Zweier and Igor A Grigor'ev and Alexandre Samouilov and Valery V Khramtsov}, journal={Magnetic resonance in medicine}, year={2012}, volume={67 6}, pages={1827-36} }