In vivo molecular imaging of chemokine receptor CXCR4 expression in patients with advanced multiple myeloma

@inproceedings{PhilippAbbrederis2015InVM,
  title={In vivo molecular imaging of chemokine receptor CXCR4 expression in patients with advanced multiple myeloma},
  author={Kathrin Philipp-Abbrederis and Ken Herrmann and Stefan Knop and Margret Schottelius and Matthias Eiber and Katharina Lueckerath and Elke Pietschmann and Stefan Habringer and Carlos Gerngross and Katharina Franke and Martina Rudelius and Andreas Schirbel and Constantin Lapa and Kristina Schwamborn and Sabine Steidle and Elena Hartmann and Andreas Rosenwald and Saskia Kropf and Ambros J. Beer and Christian Peschel and Hermann Einsele and Andreas K. Buck and Markus Schwaiger and Katharina S G{\"o}tze and Hans-J{\"u}rgen Wester and Ulrich Keller},
  booktitle={EMBO molecular medicine},
  year={2015}
}
CXCR4 is a G-protein-coupled receptor that mediates recruitment of blood cells toward its ligand SDF-1. In cancer, high CXCR4 expression is frequently associated with tumor dissemination and poor prognosis. We evaluated the novel CXCR4 probe [(68)Ga]Pentixafor for in vivo mapping of CXCR4 expression density in mice xenografted with human CXCR4-positive MM cell lines and patients with advanced MM by means of positron emission tomography (PET). [(68)Ga]Pentixafor PET provided images with… CONTINUE READING

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We evaluated the novel CXCR4 probe [ ( 68)Ga]Pentixafor for in vivo mapping of CXCR4 expression density in mice xenografted with human CXCR4-positive MM cell lines and patients with advanced MM by means of positron emission tomography ( PET ) . [
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