In vivo molecular imaging of acute and subacute thrombosis using a fibrin-binding magnetic resonance imaging contrast agent.

@article{Botnar2004InVM,
  title={In vivo molecular imaging of acute and subacute thrombosis using a fibrin-binding magnetic resonance imaging contrast agent.},
  author={Ren{\'e} M. Botnar and Alexandra S. Perez and Sonia Witte and Andrea J. Wiethoff and James Laredo and James E. Hamilton and William C Quist and Edward C Parsons and Anand Jayprakash Vaidya and Andrew F. Kolodziej and John A Barrett and Philip B Graham and Robert M. Weisskoff and Warren J. Manning and Michael T. Johnstone},
  journal={Circulation},
  year={2004},
  volume={109 16},
  pages={2023-9}
}
BACKGROUND Plaque rupture with subsequent thrombosis is recognized as the underlying pathophysiology of most acute coronary syndromes and stroke. Thus, direct thrombus visualization may be beneficial for both diagnosis and guidance of therapy. We sought to test the feasibility of direct imaging of acute and subacute thrombosis using MRI together with a novel fibrin-binding gadolinium-labeled peptide, EP-1873, in an experimental animal model of plaque rupture and thrombosis. METHODS AND… CONTINUE READING

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Pharmacokinetics, biodistribution and efficacy of EP-1873: a Gd-based fibrin specific thrombus MR agent. In: ISMRM, 11th Annual Meeting. Toronto, Canada: International Society for Magnetic Resonance

  • AJ Wiethoff, JA Barrett, JF Wang
  • 2003

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