In vivo molecular chemotherapy and noninvasive imaging with an infectivity-enhanced adenovirus.

@article{Hemminki2002InVM,
  title={In vivo molecular chemotherapy and noninvasive imaging with an infectivity-enhanced adenovirus.},
  author={Akseli Hemminki and Kurt R. Zinn and Bin Liu and Tandra R. Chaudhuri and Renee Ann Desmond and Buck E Rogers and Mack N. Barnes and Ronald D. Alvarez and David T. Curiel},
  journal={Journal of the National Cancer Institute},
  year={2002},
  volume={94 10},
  pages={741-9}
}
BACKGROUND Adenovirus-based gene therapy is a promising approach to treat advanced cancers that are resistant to other treatments. However, many primary cells lack the requisite coxsackie-adenovirus receptor (CAR), limiting the in vivo efficacy of gene therapy. Recently, a modified adenovirus that is not dependent on CAR expression for infectivity was… CONTINUE READING