In vivo modulation of a DnaJ homolog, CbpA, by CbpM.

  title={In vivo modulation of a DnaJ homolog, CbpA, by CbpM.},
  author={Matthew R Chenoweth and Nancy Trun and Sue Wickner},
  journal={Journal of bacteriology},
  volume={189 9},
CbpA, an Escherichia coli DnaJ homolog, can function as a cochaperone for the DnaK/Hsp70 chaperone system, and its in vitro activity can be modulated by CbpM. We discovered that CbpM specifically inhibits the in vivo activity of CbpA, preventing it from functioning in cell growth and division. Furthermore, we have shown that CbpM interacts with CbpA in vivo during stationary phase, suggesting that the inhibition of activity is a result of the interaction. These results reveal that the activity… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-8 of 8 extracted citations

Prokaryotic Systems Biology

Advances in Experimental Medicine and Biology • 2015

Similar Papers

Loading similar papers…