In vivo microdialysis and conditioned place preference studies in rats are consistent with abuse potential of tramadol.

@article{Sprague2002InVM,
  title={In vivo microdialysis and conditioned place preference studies in rats are consistent with abuse potential of tramadol.},
  author={Jon E Sprague and Michael Leifheit and Jennifer R. Selken and Michael M. Milks and David H. Kinder and David E. Nichols},
  journal={Synapse},
  year={2002},
  volume={43 2},
  pages={
          118-21
        }
}
The abuse potential of tramadol was investigated using both in vivo microdialysis measures of dopamine (DA) release within the nucleus accumbens (NAc) shell and the conditioned place preference (CPP) paradigm in rats. Tramadol (75 mg/kg, i.p.) induced a statistically significant increase (starting 80 min posttreatment) in DA release within the NAc shell, which was maintained for at least 120 min posttreatment. Tramadol (18.75, 37.5, and 75 mg/kg i.p.) produced a statistically significant CPP… CONTINUE READING

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