In vivo methods for drug absorption - comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects.

@article{Sjgren2014InVM,
  title={In vivo methods for drug absorption - comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects.},
  author={Erik Sj{\"o}gren and Bertil Abrahamsson and Patrick Augustijns and Dieter Becker and Michael B. Bolger and M. E. Brewster and Joachim Brouwers and Talia R Flanagan and Matthew D. Harwood and Christian A Heinen and Ren{\'e} Holm and H J Juretschke and Marlies Kubbinga and Anders Lindahl and Viera Lukacova and Uwe Muenster and Sibylle Neuhoff and Mai Anh Nguyen and Achiel van Peer and Christos Reppas and Amin Rostami Hodjegan and Christer Tannergren and Werner Weitschies and Clive Wilson and Patricia Zane and Hans Lennernaes and Peter Langguth},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2014},
  volume={57},
  pages={99-151}
}
This review summarizes the current knowledge on anatomy and physiology of the human gastrointestinal tract in comparison with that of common laboratory animals (dog, pig, rat and mouse) with emphasis on in vivo methods for testing and prediction of oral dosage form performance. A wide range of factors and methods are considered in addition, such as imaging methods, perfusion models, models for predicting segmental/regional absorption, in vitro in vivo correlations as well as models to… CONTINUE READING