In vivo metabolism of a mutant apolipoprotein, apoA-IIowa, associated with hypoalphalipoproteinemia and hereditary systemic amyloidosis.

@article{Rader1992InVM,
  title={In vivo metabolism of a mutant apolipoprotein, apoA-IIowa, associated with hypoalphalipoproteinemia and hereditary systemic amyloidosis.},
  author={Daniel J. Rader and Richard E. Gregg and Martha S. Meng and John P. R. Schaefer and Loren A. Zech and Merrill D L Benson and Hollis B Brewer},
  journal={Journal of lipid research},
  year={1992},
  volume={33 5},
  pages={755-63}
}
Apolipoprotein (apo) A-I is the major protein constituent of plasma high density lipoproteins (HDL). A kindred has been identified in which a glycine to arginine mutation at residue 26 in apoA-I is associated with hypoalphalipoproteinemia and hereditary systemic amyloidosis. We isolated the mutant protein, termed apoA-IIowa, from the plasma of an affected… CONTINUE READING