In vivo metabolism of a cholinergic false precursor after dietary administration to rats.

The false cholinergic precursor [2H4]N-amino-N,N-dimethylaminoethanol (N-aminodeanol, NADe) was fed ad libitum to weanling rats in a low choline (Ch), low methionine synthetic diet. The free [2H4]NADe plasma concentration achieved at 32 days was 51 microM. The free Ch plasma concentration was reduced to 6 microM, compared to 20 microM measured in control… CONTINUE READING