In vivo metabolism of α-methyltryptamine in rats: Identification of urinary metabolites

  title={In vivo metabolism of $\alpha$-methyltryptamine in rats: Identification of urinary metabolites},
  author={Tatsuyuki Kanamori and Kenji Kuwayama and Kenji Tsujikawa and Hajime Miyaguchi and Yuko. T. Iwata and Hiroyuki Inoue},
  pages={1476 - 1486}
1. The in vivo metabolism of α-methyltryptamine (AMT), a psychoactive tryptamine analogue, was studied in rats. 2. Male Wistar rats were administered 10 mg kg−1 AMT orally and 24-h urine fractions were collected. After enzymatic hydrolysis of the urine sample, the metabolites were extracted by liquid–liquid extraction and analysed by gas chromatography/mass spectrometry (GC/MS). 3. 2-Oxo-AMT, 6-hydroxy-AMT, 7-hydroxy-AMT and 1′-hydroxy-AMT were detected as metabolites of AMT. 

Toxicology and Analysis of Psychoactive Tryptamines

The morbidity accompanying tryptamine intake is considerable and it is critical for clinicians and laboratorians to be informed of the latest data on this public health threat.

An investigation of the stability of emerging new psychoactive substances.

This is the first time stability data have been published for these emerging substances and showed that additional compounds found during forensic casework were potential metabolites rather than instability products.

Electrochemical simulation of phase I metabolism for 21 drugs using four different working electrodes in an automated screening setup with MS detection.

Electrochemical conversion is a useful approach for the preparative synthesis of some types of metabolites, but as a screening method for unknown phase I metabolites, the method is, in this opinion, inferior to incubation with human liver microsomes and in vivo experiments with laboratory animals.

USP18 Sensitivity of Peptide Transporters PEPT1 and PEPT2

Whether USP18 modifies the activity of the peptide transporters PEPT1 and PEPt2, and whether the peptides are sensitive to the ubiquitin ligase Nedd4-2 is explored.

Toxicity of psychedelic drugs



Detection of metabolites of lysergic acid diethylamide (LSD) in human urine specimens: 2-oxo-3-hydroxy-LSD, a prevalent metabolite of LSD.

Effects in normal man of α‐methyltryptamine and α‐ethyltryptamine

These drugs were compared objectively and subjectively in a group of trained, normal human volunteers and subjective effects were recorded 3 and 24 hours after administration of the drugs.

The metabolic fate of amphetamine in man and other species.

Experiments on the precursor of 1-phenylpropan-2-one occurring in rabbit urine suggest that it might be the enol sulphate of the ketone, which was found in human and greyhound urine after acid hydrolysis.

Sensitive determination of alpha-methyltryptamine (AMT) and 5-methoxy-N,N-diisopropyltryptamine (5MeO-DIPT) in whole blood and urine using gas chromatography-mass spectrometry.

Schedules of controlled substances: placement of alpha-methyltryptamine and 5-methoxy-N,N-diisopropyltryptamine into schedule I of the Controlled Substances Act. Final rule.

  • Psychology
    Federal register
  • 2004
This final rule will continue to impose the regulatory controls and criminal sanctions of Schedule I substances on the manufacture, distribution, and possession of AMT and 5-MeO-DIPT.

A general screening and confirmation approach to the analysis of designer tryptamines and phenethylamines in blood and urine using GC-EI-MS and HPLC-electrospray-MS.

A screening method based on gas chromatography-mass spectrometry was developed and successfully applied to blood and urine samples in suspected AMT intoxications, detecting metabolites reported previously as 5-methoxy-N,N-diisopropyltryptamine-N'-oxide and 5-MeO-DiPT-N-oxide.

Tihkal : The Continuation

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48 a-MT

  • In: Joy D, editor, TiHKAL: A continuation. Berkeley, CA: Transform Press. pp. 565–569.
  • 1997

Sensitive determination of alphamethyltryptamine (AMT) and 5-methoxy-N,N-diisopropyltryptamine (5MeO-DIPT) in whole blood and urine using gas chromatography-mass spectrometry

  • Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 823:47–52.
  • 2005