In vivo mechanisms by which tumors producing thrombospondin 1 bypass its inhibitory effects.

@article{Filleur2001InVM,
  title={In vivo mechanisms by which tumors producing thrombospondin 1 bypass its inhibitory effects.},
  author={St{\'e}phanie Filleur and Olga V. Volpert and Armelle Degeorges and Carole Voland and Frank K Reiher and Philippe Cl{\'e}zardin and No{\"e}l P. Bouck and Florence Cabon},
  journal={Genes & development},
  year={2001},
  volume={15 11},
  pages={
          1373-82
        }
}
Thrombospondin 1 (TSP1) is a multifunctional protein able to activate TGFbeta and to inhibit angiogenesis in vivo. Although usually thought of as an inhibitor of tumor growth, TSP1 may sometimes be present at high levels during tumor progression, suggesting that tumors can eventually overcome their anti-tumor effects. Using a tet-repressible expression system, we demonstrate that murine TSP1 delayed the onset of tumor growth when produced in the tumor bed by rat fibrosarcoma tumor cells or by… CONTINUE READING
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