In vivo measurement of gadolinium diffusivity by dynamic contrast-enhanced MRI: a preclinical study of human xenografts.

@article{Koh2013InVM,
  title={In vivo measurement of gadolinium diffusivity by dynamic contrast-enhanced MRI: a preclinical study of human xenografts.},
  author={T. S. Koh and S. Hartono and C. H. Thng and Tony Kiat Hon Lim and Laurent Martarello and Q. S. Ng},
  journal={Magnetic resonance in medicine},
  year={2013},
  volume={69 1},
  pages={269-76}
}
Compartmental tracer kinetic models currently used for analysis of dynamic contrast-enhanced MRI data yield poor fittings or parameter values that are unphysiological in necrotic regions of the tumor, as these models only describe microcirculation in perfused tissue. In this study, we explore the use of Fick's law of diffusion as an alternative method for analysis of dynamic contrast-enhanced MRI data in the necrotic regions. Xenografts of various human cancer cell lines were implanted in 14… CONTINUE READING
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