In vivo measurement of colonic butyrate metabolism in patients with quiescent ulcerative colitis.


BACKGROUND Butyrate, a short chain fatty acid produced by bacterial fermentation, is a major fuel source for the colonocyte. In vitro work has shown that ulcerative colitis may be characterised by a metabolic defect in colonocyte butyrate oxidation. AIMS To investigate the rate of metabolism of rectally administered butyrate in patients with quiescent… (More)


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